Peer Reviewed Published Work 1973 - 2024

1. Meissner G, Conner GE, Fleischer S. Isolation of sarcoplasmic reticulum by zonal centrifugation and purification of Ca 2+ -pump and Ca 2+ -binding proteins. Biochim Biophys Acta. 1973;298(2):246-69. PubMed PMID: 4268907

2. Conner GE, Noonan NE, Noonan KD. Nuclear envelope of Chinese hamster ovary cells. Re-formation of the nuclear envelope following mitosis. Biochemistry. 1980;19(2):277-89. PubMed PMID: 7352987

3. Erickson AH, Conner GE, Blobel G. Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D. J Biol Chem. 1981;256(21):11224-31. PubMed PMID: 6116713

4. Conner GE, Nelson D, Wisniewolski R, Lahita RG, Blobel G, Kunkel HG. Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders. J Exp Med. 1982;156(5):1475-85. PubMed PMID: 7130904

5. Fisher DE, Conner GE, Reeves WH, Blobel G, Kunkel HG. Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation. Proc Natl Acad Sci U S A. 1983;80(20):6356-60. PubMed PMID: 6226047

6. Fisher DE, Reeves WH, Conner GE, Blobel G, Kunkel HG. Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies. Proc Natl Acad Sci U S A. 1984;81(10):3185-9. PubMed PMID: 6203115

7. Fisher DE, Conner GE, Reeves WH, Wisniewolski R, Blobel G. Small nuclear ribonucleoprotein particle assembly in vivo: demonstration of a 6S RNA-free core precursor and posttranslational modification. Cell. 1985;42(3):751-8. PubMed PMID: 2932224

8. Conner GE. Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme. Biochem J. 1989;263(2):601-4. PubMed PMID: 2512908

9. Conner GE, Udey JA, Pinto C, Sola J. Nonhuman cells correctly sort and process the human lysosomal enzyme cathepsin D. Biochemistry. 1989;28(8):3530-3. PubMed PMID: 2742852

10. Wang M, Scott WA, Rao KR, Udey J, Conner GE, Brew K. Recombinant bovine alpha-lactalbumin obtained by limited proteolysis of a fusion protein expressed at high levels in Escherichia coli. J Biol Chem. 1989;264(35):21116-21. PubMed PMID: 2687274

11. Conner GE, Udey JA. Expression and refolding of recombinant human fibroblast procathepsin D. DNA Cell Biol. 1990;9:1-9. PubMed PMID: 2180427

12. Richo G, Conner GE. Proteolytic activation of human procathepsin D. Adv Exp Med Biol. 1991;306:289-96. PubMed PMID: 1812719

13. Scarborough PE, Richo GR, Kay J, Conner GE, Dunn BM. Comparison of kinetic properties of native and recombinant human cathepsin D. Adv Exp Med Biol. 1991;306:343-7. PubMed PMID: 1812725

14. Conner GE, Richo G. Isolation and characterization of a stable activation intermediate of the lysosomal aspartyl protease cathepsin D. Biochemistry. 1992;31(4):1142-7. PubMed PMID: 1734961

15. Conner GE. The role of the cathepsin D propeptide in sorting to the lysosome. J Biol Chem. 1992;267(30):21738-45. PubMed PMID: 1400484

16. Milde KF, Conner GE, Mintz DH, Alejandro R. Primary structure of the canine CD4 antigen. Biochim Biophys Acta. 1993;1172(3):315-8. PubMed PMID: 7916632

17. Scarborough PE, Guruprasad K, Topham C, Richo GR, Conner GE, Blundell TL, Dunn BM. Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling. Protein Sci. 1993;2(2):264-76. PubMed PMID: 8443588

18. Richo GR, Conner GE. Structural requirements of procathepsin D activation and maturation. J Biol Chem. 1994;269(20):14806-12. PubMed PMID: 8182087

19. Zhu Y, Conner GE. Intermolecular association of lysosomal protein precursors during biosynthesis. J Biol Chem. 1994;269(5):3846-51. PubMed PMID: 8106429

20. Abramson SR, Conner GE, Nagase H, Neuhaus I, Woessner JF, Jr. Characterization of rat uterine matrilysin and its cDNA. Relationship to human pump-1 and activation of procollagenases. J Biol Chem. 1995;270(27):16016-22. PubMed PMID: 7608162

21. Salathe M, Guldimann P, Conner GE, Wanner A. Hydrogen peroxide-scavenging properties of sheep airway mucus. Am J Respir Crit Care Med. 1995;151(5):1543-50. PubMed PMID: 7735613

22. Nadji M, Fresno M, Nassiri M, Conner G, Herrero A, Morales AR. Cathepsin D in Host Stromal Cells, but Not in Tumor Cells, Is Associated With Aggressive Behaviour in Node-Negative Breast Cancer. Hum Pathol. 1996;27:890-5. PubMed PMID: 8816882

23. Hiraiwa M, Martin BM, Kishimoto Y, Conner GE, Tsuji S, O'Brien JS. Lysosomal proteolysis of prosaposin, the precursor of saposins (sphingolipid activator proteins): its mechanism and inhibition by ganglioside. Arch Biochem Biophys. 1997;341(1):17-24. PubMed PMID: 9143348

24. Salathe M, Holderby M, Forteza R, Abraham WM, Wanner A, Conner GE. Isolation and characterization of a peroxidase from the airway. Am J Respir Cell Mol Biol. 1997;17(1):97-105. PubMed PMID: 9224215

25. Chinni SR, Gercel-Taylor C, Conner GE, Taylor DD. Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients. Cancer Immunol Immunother. 1998;46(1):48-54. PubMed PMID: 9520292

26. Forteza R, Lauredo I, Abraham WM, Conner GE. Bronchial tissue kallikrein activity is regulated by hyaluronic acid binding. Am J Respir Cell Mol Biol. 1999;21(6):666-74. PubMed PMID: 10572063

27. Gerson C, Sabater J, Scuri M, Torbati A, Coffey R, Abraham JW, Lauredo I, Forteza R, Wanner A, Salathe M, Abraham WM, Conner GE. The lactoperoxidase system functions in bacterial clearance of airways. Am J Respir Cell Mol Biol. 2000;22(6):665-71. PubMed PMID: 10837362

28. Conner GE, Forteza R, Salathe M, Randell SH, Fernandez V. Impaired thiocyanate transport in cystic fibrosis leads to an altered lactoperoxidase antibacterial system. Am J Respir Crit Care Med. 2001;163:A409. (Conference abstract; no PMID)

29. Forteza R, Lieb T, Aoki T, Savani RC, Conner GE, Salathe M. Hyaluronan serves a novel role in airway mucosal host defense. FASEB J. 2001;15(12):2179-86. PubMed PMID: 11641244

30. Horvath G, Lieb T, Conner GE, Salathe M, Wanner A. Steroid sensitivity of norepinephrine uptake by human bronchial arterial and rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol. 2001;25(4):500-6. PubMed PMID: 11694456

31. Conner GE, Salathe M, Forteza R. Lactoperoxidase and hydrogen peroxide metabolism in the airway. Am J Respir Crit Care Med. 2002;166(12 Pt 2):S57-61. PubMed PMID: 12471090

32. Forteza RM, Conner G, Salathe M. Hyaluronan and Airway Mucosal Host Defense. GlycoForum. 2002. (Book chapter; no PMID)

33. Horvath G, Torbati A, Conner GE, Salathe M, Wanner A. Systemic ovalbumin sensitization downregulates norepinephrine uptake by rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol. 2002;27(6):746-51. PubMed PMID: 12444035

34. Nlend MC, Bookman RJ, Conner GE, Salathe M. Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia. Am J Respir Cell Mol Biol. 2002;27(4):436-45. PubMed PMID: 12356577

35. Salathe M, Forteza R, Conner GE. Post-secretory fate of host defence components in mucus. Novartis Found Symp. 2002;248:20-6; discussion 7-37, 277-82. PubMed PMID: 12568486

36. El-Chemaly S, Salathe M, Baier S, Conner GE, Forteza R. Hydrogen peroxide-scavenging properties of normal human airway secretions. Am J Respir Crit Care Med. 2003;167(3):425-30. PubMed PMID: 12446267

37. Horvath G, Sutto Z, Torbati A, Conner GE, Salathe M, Wanner A. Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. American journal of physiology Lung cellular and molecular physiology. 2003;285(4):L829-37. PubMed PMID: 12807698

38. Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, Gerson C, Cobas MA, Forteza R, Salathe M, Conner GE. Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol. 2003;29(2):206-12. PubMed PMID: 12626341

39. Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL. Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol. 2004;30(2):184-92. PubMed PMID: 12920053

40. Casalino-Matsuda SM, Monzon ME, Conner GE, Salathe M, Forteza RM. Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways. J Biol Chem. 2004;279(20):21606-16. PubMed PMID: 14988406

41. Forteza R, Conner GE, Salathe M. Hyaluronan in the airways. In: Hales HGGaCA, editor. Chemistry and Biology of Hyaluronan: Elsevier; 2004. p. 323-37. (Book chapter; no PMID)

42. Fragoso MA, Fernandez V, Forteza R, Randell SH, Salathe M, Conner GE. Transcellular thiocyanate transport by human airway epithelia. J Physiol (London). 2004;561(Pt 1):183-94. PubMed PMID: 15345749

43. Sutto Z, Conner GE, Salathe M. Regulation of human airway ciliary beat frequency by intracellular pH. J Physiol (London). 2004;560(Pt 2):519-32. PubMed PMID: 15308676

44. Forteza R, Salathe M, Miot F, Forteza R, Conner GE. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32(5):462-9. PubMed PMID: 15677770

45. Schmid A, Bai G, Schmid N, Zaccolo M, Ostrowski LE, Conner GE, Fregien N, Salathe M. Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells. J Cell Sci. 2006;119(20):4176-86. PubMed PMID: 16984973

46. Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L, Muimo R. The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function. Mol Biol Cell. 2007;18(9):3388-97. PubMed PMID: 17581860

47. Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M. The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett. 2007;581(2):271-8. PubMed PMID: 17204267

48. Horvath G, Schmid N, Fragoso MA, Schmid A, Conner GE, Salathe M, Wanner A. Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am J Respir Cell Mol Biol. 2007;36(1):53-60. PubMed PMID: 16917073

49. Horvath G, Mendes ES, Schmid N, Schmid A, Conner GE, Salathe M, Wanner A. The effect of corticosteroids on the disposal of long-acting beta2-agonists by airway smooth muscle cells. J Allergy Clin Immunol. 2007;120(5):1103-9. PubMed PMID: 17920670

50. Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M. Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. FEBS Lett. 2007;581(17):3241-6. PubMed PMID: 17586501

51. Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, Buck J, Levin LR, Conner GE, Fregien N, Salathe M. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol. 2007;130(1):99-109. PubMed PMID: 17591988

52. Fragoso MA, Torbati A, Fregien N, Conner GE. Molecular heterogeneity and alternative splicing of human lactoperoxidase. Arch Biochem Biophys. 2009;482(1-2):52-7. PubMed PMID: 19059195

53. Gattas MV, Forteza R, Fragoso MA, Fregien N, Salas P, Salathe M, Conner GE. Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med. 2009;47(10):1450-8. PubMed PMID: 19703552

54. Ransford GA, Fregien N, Qiu F, Dahl G, Conner GE, Salathe M. Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009;41(5):525-34. PubMed PMID: 19213873

55. Schmid A, Sutto Z, Schmid N, Novak L, Ivonnet P, Horvath G, Conner G, Fregien N, Salathe M. Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem. 2010;285(39):29998-30007. PubMed PMID: 20639512

56. Horvath G, Mendes ES, Schmid N, Schmid A, Conner GE, Fregien NL, Salathe M, Wanner A. Rapid nongenomic actions of inhaled corticosteroids on long-acting beta(2)-agonist transport in the airway. Pulm Pharmacol Ther. 2011;24(6):654-9. PubMed PMID: 21914487

57. Manzanares D, Gonzalez C, Ivonnet P, Chen RS, Valencia-Gattas M, Conner GE, Larsson HP, Salathe M. Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume. J Biol Chem. 2011;286(22):19830-9. PubMed PMID: 21454692

58. Martens CJ, Inglis SK, Valentine VG, Garrison J, Conner GE, Ballard ST. Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi. Am J Physiol Lung Cell Mol Physiol. 2011;301(2):L236-46. PubMed PMID: 21622844

59. Unwalla HJ, Horvath G, Roth FD, Conner GE, Salathe M. Albuterol modulates its own transepithelial flux via changes in paracellular permeability. Am J Respir Cell Mol Biol. 2012;46(4):551-8. PubMed PMID: 22162907

60. Conner GE, Ivonnet P, Gelin M, Whitney P, Salathe M. H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4. Am J Respir Cell Mol Biol. 2013;49(4):672-9. PubMed PMID: 23742099

61. Adams KM, Abraham V, Spielman D, Kolls JK, Rubenstein RC, Conner GE, Cohen NA, Kreindler JL. IL-17A Induces Pendrin Expression and Chloride-Bicarbonate Exchange in Human Bronchial Epithelial Cells. PLoS ONE. 2014;9(8):e103263. PubMed PMID: 25141009

62. Gerovac BJ, Valencia M, Baumlin N, Salathe M, Conner GE, Fregien NL. Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am J Respir Cell Mol Biol. 2014;51(4):516-25. PubMed PMID: 24754775

63. Manzanares D, Srinivasan M, Salathe ST, Ivonnet P, Baumlin N, Dennis JS, Conner GE, Salathe M. IFN-gamma-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. Am J Physiol Lung Cell Mol Physiol. 2014;306(5):L453-62. PubMed PMID: 24414257

64. Ivonnet P, Salathe M, Conner GE. Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. Br J Pharmacol. 2015;172(1):173-84. PubMed PMID: 25220136

65. Unwalla HJ, Ivonnet P, Dennis JS, Conner GE, Salathe M. Transforming growth factor-beta1 and cigarette smoke inhibit the ability of beta2-agonists to enhance epithelial permeability. Am J Respir Cell Mol Biol. 2015;52(1):65-74. PubMed PMID: 24978189

66. Dahl GP, Conner GE, Qiu F, Wang J, Spindler E, Campagna JA, Larsson HP. High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure. EBioMedicine. 2016;10:291-7. PubMed PMID: 27349457

67. Ivonnet P, Unwalla H, Salathe M, Conner GE. Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. Respir Res. 2016;17:15. PubMed PMID: 26857816

68. Valencia-Gattas M, Conner GE, Fregien NL. Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery. PLoS ONE. 2016;11(8):e0160216. PubMed PMID: 27532261

69. Burgueno JF, Fritsch J, Santander AM, Brito N, Fernandez I, Pignac-Kobinger J, Conner GE, Abreu MT. Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing H2O2. Frontiers in physiology. 2019;10:1484. PubMed PMID: 31871440

70. Kerr NA, de Rivero Vaccari JP, Umland O, Bullock MR, Conner GE, Dietrich WD, Keane RW. Human Lung Cell Pyroptosis Following Traumatic Brain Injury. Cells. 2019;8(1). PubMed PMID: 30669285

71. Gattas MV, Jaffe A, Barahona J, Conner GE. Proton channel blockers inhibit Duox activity independent of Hv1 effects. Redox biology. 2020;28:101346. PubMed PMID: 31678720

72. Burgueno JF, Fritsch J, Gonzalez EE, Landau KS, Santander AM, Fernandez I, Hazime H, Davies JM, Santaolalla R, Phillips MC, Diaz S, Dheer R, Brito N, Pignac-Kobinger J, Fernandez E, Conner GE, Abreu MT. Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis. Gastroenterology. 2021;160(3):797-808 e6. PubMed PMID: 33127391

73. Conner GE. Regulation of dual oxidase hydrogen peroxide synthesis results in an epithelial respiratory burst. Redox biology. 2021;41:101931. PubMed PMID: 33743241

74. Conner GE. NADPH Alters DUOX1 Calcium Responsiveness. Redox biology. 2024;75:103251. PubMed PMID: 38936256